Originally part of a larger estate belonging to Arnaud de Lestonnac, before being acquired by Pères Lazaristes in 1540, the congregation of priests would develop the vineyards significantly. The name « La Mission » was added during the time the Lazarists priests operated the estate. Confiscated by the state during the French Revolution before being purchased in 1821 by Martial-Victor Vaillant. The estate was purchased by Domaine Clarence Dillon in 1983, managed alongside Château Haut-Brion.